Myeloperoxidase-deficient neutrophils in acute myeloid leukaemia.
Myeloperoxidase-deficient neutrophils in acute myeloid leukaemia.
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急性髓系白血病中缺乏髓过氧化物酶的中性粒细胞。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
J. Robinson
中科院分区：
文献类型：
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作者：
D. Catovsky;D. Galton;J. Robinson
在28例急性髓性白血病（AML）中有12例（43%）和7例慢性粒细胞白血病的“母细胞转化”中有2例（28%）发现缺乏髓过氧化物酶（MP）的多形中性粒细胞（PMN）。这种异常，当存在时，影响8%至70%的循环PMN。在AML中，这在成髓细胞和红白血病类型中比在主要单核细胞分化和高血清和尿溶菌酶浓度的AML中更常见。奥尔杆在伴有MP-阴性PMN的AML病例的原始细胞中多见3.3倍，这种相关性非常显著（p > 0.01）。低中性粒细胞碱性磷酸酶也经常与缺乏MP。有人建议，这些异常可能会导致从白血病干细胞来源的细胞中的高尔基复合体的功能紊乱。MP损害中性粒细胞的杀菌能力，可能是一个重要的因素，除了中性粒细胞减少症，在这些患者的细菌感染的易感性增加。
Polymorphonuclear neutrophils (PMN) lacking myeloperoxidase (MP) were found in 12 out of 28 (43 %) cases of acute myeloid leukaemia (AML) and in 2 out of 7 (28 %) cases of ‘blast-cell transformation’ of chronic granulocytic leukaemia. This abnormality, when present, affected 8 % to 70 % of the circulating PMN. In AML this was much more common in the myeloblastic and erythroleukaemic varieties than in those with predominantly monocytic differentiation and high serum and urinary lysozyme concentrations. Auer rods were 3.3 times more common in the blast cells of AML cases with MP-negative PMN; this correlation was highly significant (p > 0.01). Low neutrophil alkaline phosphatase was also frequently associated with absence of MP. It is suggested that these abnormalities could result from a disturbance in the function of the Golgi complex in cells derived from leukaemic stem lines. MP impairs the bactericidal capacity of PMN and may be an important factor, in addition to neutropenia, in the increased susceptibility to bacterial infections in these patients.