Diverging trends in the incidence of reflux-related and Helicobacter pylori-related gastric cardia cancer.
Diverging trends in the incidence of reflux-related and Helicobacter pylori-related gastric cardia cancer.
复制标题
DOI：
10.1097/mcg.0b013e318260177a
复制
发表时间：
2013-04
影响因子：
2.9
通讯作者：
Neugut AI
中科院分区：
文献类型：
--
作者：
Abrams JA;Gonsalves L;Neugut AI
描述贲门癌两种亚型的历史发病趋势。贲门癌的发病率在西方国家有上升趋势。先前的研究将贲门癌作为单一实体进行治疗，但最近的数据表明有两种不同的亚型：反流相关和幽门螺杆菌相关。我们使用1955-2007年康涅狄格州肿瘤登记数据进行了一项基于人群的研究。计算胃癌（整体和解剖亚部位）和食管腺癌的经胃镜校正的发病率（每10万人-年）。进一步调整贲门癌和非贲门癌的发生率，以解释未指明亚部位的病例。推导出计算反流相关和H.幽门相关的贲门癌贲门癌的调整后发病率在1955-59年为每10万人4.0例，1965-69年下降到每10万人2.4例，2003-07年上升到每10万人3.4例。H.在研究期间，幽门相关贲门癌从每10万人3.7例下降到1.0例，而反流相关贲门癌从每10万人0.3例逐渐增加到2.4例。反流相关的贲门癌和食管腺癌的曲线彼此密切对应，它们的合并发病率从1955-59年的0.5/10万上升到2003-07年的5.6/10万。反流相关的贲门癌的发病率稳步上升，而H。自世纪中期以来，幽门相关的贲门癌已经逐渐减少。反流相关的贲门癌和食管腺癌发病率的趋势非常相似，表明这两种癌症具有相似的病因学和病理生理过程。
To describe historical incidence trends of two subtypes of gastric cardia cancer. The incidence of gastric cardia cancer has increased in western countries. Prior studies have treated cardia cancer as a single entity, but recent data suggest that there are two distinct subtypes: reflux-related and Helicobacter pylori-related. We conducted a population-based study using Connecticut Tumor Registry data from 1955–2007. Age-adjusted incidence rates (per 100,000 person-years) were calculated for gastric cancer, as a whole and by anatomic subsite, and for esophageal adenocarcinoma. Cardia and non-cardia cancer incidence rates were further adjusted to account for cases with unspecified subsite. Mathematical formulas were derived to calculate incidence rates for reflux-related and H. pylori-related cardia cancer. The adjusted incidence of cardia cancer was 4.0 per 100,000 in 1955–59, decreased to 2.4 per 100,000 in 1965–69 before increasing to 3.4 per 100,000 by 2003–07. The incidence of H. pylori-related cardia cancer decreased from 3.7 to 1.0 per 100,000 over the study period, whereas reflux-related cardia cancer increased progressively from 0.3 to 2.4 per 100,000. The curves for reflux-related cardia cancer and esophageal adenocarcinoma closely mirrored each other, and their combined incidence rose from 0.5 per 100,000 in 1955–59 to 5.6 per 100,000 in 2003–07. The incidence of reflux-related cardia cancer has steadily increased, while H. pylori-related cardia cancer has declined progressively since the mid-20th century. Trends in reflux-related cardia cancer and esophageal adenocarcinoma incidence are very similar, suggesting that these two cancers share a similar etiology and pathophysiologic process.