Parietal Cortex Integrates Saccade and Object Orientation Signals to Update Grasp Plans
Parietal Cortex Integrates Saccade and Object Orientation Signals to Update Grasp Plans
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DOI：
10.1523/jneurosci.0300-20.2020
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发表时间：
2020-06-03
影响因子：
5.3
通讯作者：
Crawford, J. Douglas
中科院分区：
文献类型：
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作者：
Baltaretu, Bianca R.;Monaco, Simona;Crawford, J. Douglas
协调的伸手抓握运动通常伴随着快速的眼睛运动（扫视），其相对于视网膜移位期望的物体图像。顶叶皮层通过更新相对于当前注视方向的到达目标来补偿这一点，但其在更新抓握计划的视神经和视觉方向信号的整合中的作用尚不清楚。基于最近的感知实验，我们假设，下顶叶皮层（特别是边缘上回[SMG]）整合扫视和视觉信号，以更新掌握计划在额外的顶内/上级顶叶区域。为了在人类（7名女性，6名男性）中测试这一假设，我们使用了功能性磁共振范例，其中扫视有时会中断对一个简短呈现的对象的抓握准备，该对象后来在运动之前重新出现（具有相同/不同的方向）。右SMG和几个顶叶抓握区域，即左前顶内沟和双侧上级顶叶小叶，符合我们的跨扫视方向整合的标准：他们表现出任务依赖性扫视调制，并在把握执行，他们特别敏感的对象方向，随后扫视的变化。最后，SMG显示出与前额叶扫视区域（与眼球输入一致）和前顶内沟/上级顶叶小叶（与感觉运动输出一致）的功能连接增强。这些结果支持顶叶皮层的视觉空间扰动的整合的一般作用，并提供特定的皮层模块的整合眼和视觉信号的把握更新。
Coordinated reach-to-grasp movements are often accompanied by rapid eye movements (saccades) that displace the desired object image relative to the retina. Parietal cortex compensates for this by updating reach goals relative to current gaze direction, but its role in the integration of oculomotor and visual orientation signals for updating grasp plans is unknown. Based on a recent perceptual experiment, we hypothesized that inferior parietal cortex (specifically supramarginal gyrus [SMG]) integrates saccade and visual signals to update grasp plans in additional intraparietal/superior parietal regions. To test this hypothesis in humans (7 females, 6 males), we used a functional magnetic resonance paradigm, where saccades sometimes interrupted grasp preparation toward a briefly presented object that later reappeared (with the same/different orientation) just before movement. Right SMG and several parietal grasp regions, namely, left anterior intraparietal sulcus and bilateral superior parietal lobule, met our criteria for transsaccadic orientation integration: they showed task-dependent saccade modulations and, during grasp execution, they were specifically sensitive to changes in object orientation that followed saccades. Finally, SMG showed enhanced functional connectivity with both prefrontal saccade regions (consistent with oculomotor input) and anterior intraparietal sulcus/superior parietal lobule (consistent with sensorimotor output). These results support the general role of parietal cortex for the integration of visuospatial perturbations, and provide specific cortical modules for the integration of oculomotor and visual signals for grasp updating.