Structure and function of retinoid-binding proteins.
Structure and function of retinoid-binding proteins.
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类视黄醇结合蛋白的结构和功能。
DOI：
10.1007/978-1-4899-1789-8_3
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Ong,DE
中科院分区：
文献类型：
--
作者：
Newcomer,ME;Jamison,RS;Ong,DE
需要从维生素A(视黄醇)中提取化合物的生物过程包括形态发生、精子发生、上皮组织的维持和视觉。对于最后一个过程，光激活视紫红质结合的视黄醛的顺反异构化触发了一系列事件，最终导致环状GMP的水解。对于形态发生、精子发生和上皮组织的维持，维甲酸可能是活性代谢物。9-顺式和全反式维甲酸都是转录激活剂，通过与核蛋白结合发挥作用，核蛋白是包括类固醇激素受体在内的超家族成员。多种蛋白质调节疏水性维生素的运输和代谢，从而调节细胞核可获得的维甲酸浓度。细胞外和细胞内的维甲酸结合蛋白都已被鉴定。
Biological processes which require compounds derived from vitamin A (retinol) include morphogenesis, spermatogenesis, the maintenance of epithelial tissue, and vision. For the last process the light-activated cis-trans isomerization of rhodopsin-bound retinaldehyde triggers a cascade of events which ultimately results in the hydrolysis of cyclic GMP. For morphogenesis, spermatogenesis, and the maintenance of epithelial tissue it is presumably retinoic acid that is the active metabolite. Both 9-cis and all-trans retinoic acid are transcriptional activators which exert their effects through binding to nuclear proteins that are members of the superfamily that includes the steroid hormone receptors. Various proteins mediate the transport and metabolism of the hydrophobic vitamin and consequently modulate the concentration of retinoic acid available to the nucleus. Both extracellular and intracellular retinoid-binding proteins have been identi-