Deviant matters:: Duration, frequency, and intensity deviants reveal different patterns of mismatch negativity reduction in early and late schizophrenia
Deviant matters:: Duration, frequency, and intensity deviants reveal different patterns of mismatch negativity reduction in early and late schizophrenia
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DOI：
10.1016/j.biopsych.2007.02.016
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发表时间：
2008-01-01
影响因子：
10.6
通讯作者：
Naatanen, Risto
中科院分区：
文献类型：
--
作者：
Todd, Juanita;Michie, Patricia T.;Naatanen, Risto
背景资料：在精神分裂症中，被称为失配负波（MMN）的听觉事件相关电位成分的大小减少是一个一致的发现。本研究的目的是检验假设，声音强度和持续时间可能是更敏感的MMN减少早期精神分裂症的发展，因为计算复杂性，在提取这两个声音的尺寸。在持续时间，频率或强度偏离的声音引起的MMN被测量，（n = 14，平均2.6年）和较长的疾病长度（n = 29，平均18.9年）相对于健康的年龄匹配的对照subjects.Results：对于参与者在疾病的早期，一个明确的减少是明显的MMN的持续时间和强度，但不是频率偏差。一个不同的模式，观察到在患者较长的疾病长度，即减少频率和持续时间的程度较低，但不是强度MMN.Conclusions：结果表明，一个显着的年龄相关性下降的持续时间和强度MMN在对照组中，可能会降低这些指标的敏感性，在精神分裂症的发病过程中，稍后测量。引起不同的声音特性的变化的MMN提供了潜在的补充信息的发病和进展的神经病理变化的基础MMN减少精神分裂症。
Background: A reduction in the size of the auditory event-related potential component known as Mismatch negativity (MMN) is a consistent finding in schizophrenia. This study was designed to test the hypothesis that sound intensity and duration might be more sensitive to MMN reduction early in the development of schizophrenia because of the computational complexity in extracting these two sound dimensions.Methods: The MMN elicited to sounds deviating in duration, frequency, or intensity was measured in participants with a short (n = 14, mean 2.6 years) and longer length of illness (n = 29, mean 18.9 years) relative to healthy age-matched control subjects.Results: For participants early in the illness, a clear reduction was evident in MMN to duration and intensity but not frequency deviants. A different pattern was observed in patients with a longer length of illness-that is, a reduction in frequency and in duration to a lesser degree but not intensity MMN.Conclusions: The results indicate a pronounced age-related decline in duration and intensity MMN in control subjects that might reduce the sensitivity of these indices in schizophrenia when measured later in the course of the illness. The MMN elicited to changes in different sound properties provides potentially complementary information on the onset and progression of neuropathological changes that underlie the reduction in MMN in schizophrenia.