The roles of exosomal immune checkpoint proteins in tumors.

The roles of exosomal immune checkpoint proteins in tumors.
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外泌体免疫检查点蛋白在肿瘤中的作用

DOI:
10.1186/s40779-021-00350-3
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发表时间:
2021-11-08
影响因子:
21.1
通讯作者:
Peng HL
Peng HL
中科院分区:
医学1区
文献类型:
--
作者:
Xing C;Li H;Li RJ;Yin L;Zhang HF;Huang ZN;Cheng Z;Li J;Wang ZH;Peng HL

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靶向免疫检查点在治疗早期肿瘤方面取得了很大的治疗效果。然而,大多数患者对这种疗法产生适应性抵抗力。最新证据表明,肿瘤来源的外切体可能在全身免疫抑制和肿瘤进展中发挥关键作用。在本文中,我们重点介绍了胞外免疫检查点蛋白在肿瘤免疫中的作用,重点介绍了程序性死亡配体1(PD-L1)和细胞毒性T淋巴细胞相关抗原4(CTLA-4),以及外体表达的T细胞免疫球蛋白-3(Tim-3)、精氨酸酶1(ARG1)和雌激素受体结合片段相关抗原9(EBAG9)的作用。
Targeting immune checkpoints has achieved great therapeutic effects in the treatment of early-stage tumors. However, most patients develop adaptive resistance to this therapy. The latest evidence demonstrates that tumor-derived exosomes may play a key role in systemic immune suppression and tumor progression. In this article, we highlight the role of exosomal immune checkpoint proteins in tumor immunity, with an emphasis on programmed death ligand 1 (PD-L1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), as well as emerging evidence on roles of T cell immunoglobulin-3 (TIM-3), arginase 1 (ARG1), and estrogen receptor binding fragment-associated antigen 9 (EBAG9) expressed by exosomes.
DOI: 10.1007/s10147-016-0959-z
发表时间: 2016-06
影响因子: 3.3
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