EXCITABILITY CHANGES OF THE MAUTHNER CELL DURING COLLATERAL INHIBITION.
EXCITABILITY CHANGES OF THE MAUTHNER CELL DURING COLLATERAL INHIBITION.
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DOI：
10.1085/jgp.48.4.581
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发表时间：
1965-03
影响因子：
3.8
通讯作者：
ASADA, Y
中科院分区：
文献类型：
--
作者：
FUKAMI, Y;FURUKAWA, T;ASADA, Y
通过通过细胞内电极施加电流脉冲刺激金鱼毛特纳细胞(M细胞)，直接测量了在侧枝抑制过程中兴奋性的变化。兴奋性在外源性超极化电位(EHP)和侧支IPSP期间受到抑制。EHP的抑制作用在强度上与IPSP相当。在侧支IPSP期间，M细胞兴奋性的变化依赖于膜电导和膜电位的变化。提出了一些简单的方程，用膜电位和电导的变化来描述IPSP过程中兴奋性的变化。研究还发现，逆行冲动对M细胞的侵袭在EHP过程中被抑制，但在侧枝IPSP过程中不被抑制。IPSP过程中电导的增加不干扰逆行脉冲的侵入。
Excitability changes during collateral inhibition of the goldfish Mauthner cell (M cell) were measured directly by stimulating the cell with current pulses applied through an intracellular electrode. Excitability was suppressed during the extrinsic hyperpolarizing potential (EHP) as well as during the collateral IPSP. The inhibitory effect of the EHP was shown to be comparable in intensity to the effect of the IPSP. Excitability changes in the M cell during collateral IPSP depended on changes in the membrane conductance as well as in the membrane potential. Some simple equations are advanced which describe the excitability change during the IPSP in terms of changes in membrane potential and conductance. It was also found that invasion of antidromic impulses into the M cell was suppressed during the EHP, but not during the collateral IPSP. Conductance increase during the IPSP did not interfere with the invasion of antidromic impulses.