Hemorrhage in development of the face.
Hemorrhage in development of the face.
复制标题
面部发育过程中出血。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
D. Poswillo
中科院分区：
文献类型：
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作者：
D. Poswillo
胚胎发育早期的局灶性发育可能在特定畸形的发病机制中起重要作用。半面侏儒和沙利度胺诱导的耳下颌骨发育不全的动物模型进行了描述;畸形的因果机制似乎是密切相关的，在镫骨动脉系统的发展时形成的血肿。血肿对形态发生的影响进行了描述，并在动物模型中观察到的变化与人类类似的异常。
Focal hemorrhages, early in embryogenesis, may play a significant part in the pathogenesis of specific malformations. Animal models of hemifacial microsomia and thalidomide-induced otomandibular dysostosis are described; the causal mechanism of malformation appeared to be closely related to the formation of a hematoma at the time of development of the stapedial arterial systems. The effects of the hematoma on morphogenesis are described, and the changes observed in the animal models compared with similar anomalies in man.