Neurologic abnormalities in infantile autism
Neurologic abnormalities in infantile autism
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DOI：
10.1177/088307389601100204
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发表时间：
1996-03-01
影响因子：
1.9
通讯作者：
YeungCourchesne, R
中科院分区：
文献类型：
--
作者：
Haas, RH;Townsend, J;YeungCourchesne, R
神经解剖学、病理学和神经行为研究表明自闭症患者存在小脑和顶叶异常。我们使用标准化方案对28名儿童自闭症患者和24名儿童正常健康志愿者进行神经功能检查。作为一个组，自闭症受试者接受了磁共振成像的定量测量，显示小脑蚯蚓发育不良或增生，以及测量后穹隆体示后皮质异常。在反映小脑和顶叶功能的测试中，自闭症患者的临床检查可检测到的神经异常明显高于正常对照组。这些研究证实，自闭症患者的结构和行为缺陷确实会导致在临床神经学检查中可以检测到的异常。
Neuroanatomic, pathologic, and neurobehavioral studies point to a cerebellar and parietal abnormality in autism. We used a standardized protocol to examine neurologic function in 28 pediatric autistic subjects and 24 pediatric normal healthy volunteer controls. As a group, the autistic subjects had quantitative measures from magnetic resonance imaging suggesting hypoplasia or hyperplasia of the cerebellar vermis, as well as measurements of posterior corpus callosum suggesting abnormalities of posterior cortex. In groups of tests that reflect cerebellar and parietal function, the neurologic abnormalities detectable by clinical examination were significantly greater for autistic subjects than for normal controls. These studies confirm that the structural and behavioral deficit in autism does lead to abnormalities that can be detected on the clinical neurologic examination.