Recent Progress and Development of Crystal Structure Analysis of Enzymes and Other Proteins
Recent Progress and Development of Crystal Structure Analysis of Enzymes and Other Proteins
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酶和其他蛋白质晶体结构分析的最新进展和进展
DOI：
10.5940/jcrsj.52.8
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发表时间：
2010
影响因子：
4.4
通讯作者：
M. Okai
中科院分区：
文献类型：
--
作者：
M. Tanokura;K. Nagata;K. Miyazono;T. Miyakawa;M. Okai
结构生物学在这十年中取得了巨大的进步。本文简要介绍了日本文部科学省(MEXT)推动的国家级项目--目标蛋白质研究计划。该计划旨在揭示蛋白质的结构和功能，这些蛋白质在学术研究和工业应用中都非常重要。我们还总结了(I)用于抗旱和耐热作物育种的转录调控蛋白、(Ii)用于产生手性化合物的有用酶和(Iii)用于降解环境污染物质的有用酶的结构-功能分析的结果。这些成果可用于工业的各个领域，以提高粮食生产，提高药物化合物生产的效率，并促进受污染土壤和水的生物修复。
Structural biology has made tremendous progress in this decade. Here we briefly introduce the Target Proteins Research Program, a national project promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. The program aims to reveal the structure and function of proteins that are of great importance in both academic research and industrial application. We also summarize the results of structure-function analyses of (i) transcriptional regulatory proteins useful for the breading of drought and heat stress tolerant crops, (ii) useful enzymes for the production of chiral compounds, and (iii) useful enzymes for the degradation of environmental pollution substances. These results can be utilized in various areas of industries, to enhance food production, to improve the efficiency of pharmaceutical compound production, and to promote the bioremediation of contaminated soil and water.
来自马其顿念珠菌的老黄酶催化酮异佛尔酮 C=C 键的立体特异性还原
影响因子：
1.6
作者：
Kataoka, M;Kotaka, A;Shimizu, S
通讯作者：
Shimizu, S