Noninvasive determination of hemoglobin saturation in dogs by derivative near-infrared spectroscopy.
Noninvasive determination of hemoglobin saturation in dogs by derivative near-infrared spectroscopy.
复制标题
通过衍生近红外光谱法无创测定狗的血红蛋白饱和度。
DOI：
10.1152/ajpheart.1989.256.5.h1493
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Traystman,RJ
中科院分区：
文献类型：
--
作者：
Ferrari,M;Wilson,DA;Hanley,DF;Hartmann,JF;Rogers,MC;Traystman,RJ
建立了一种利用导数近红外光谱无创检测脑静脉血氧饱和度(SVO2)的活体方法。该方法在8只戊巴比妥钠麻醉的狗身上进行了测试，这些狗用不同的氧气混合物进行呼吸，以迫使SVO2在很大范围内发生变化。通过透光上矢状窦周围组织获得的光谱数据被转换为一阶导数单位，用于与从上矢状窦测量的SVO2数据相关联。对5只狗的数据进行了线性回归分析，并用它建立了一个预测大脑SVO2的三波长算法。在三只狗中，SvO2被改变以测试该方程预测SvO2的能力。从31个不同的光谱预测的SVO2与实测值之间的标准偏差为3.2%。当将这些预测值与采样的SVO2进行回归时，得到的r值为0.97。结果表明，在缺氧性缺氧(HH)过程中，利用红外光谱对SVO2进行无创性定量是可能的。
An in vivo method utilizing derivative near-infrared spectroscopy was developed to noninvasively determine cerebral venous hemoglobin O2 saturation (SVO2). The method was tested on eight pentobarbital-anesthetized dogs ventilated with differing inspired O2 mixtures to force changes in SVO2 over a wide range. Spectral data obtained by transilluminating the tissues surrounding the superior sagittal sinus (SS) were transformed into first derivative units for correlation with SVO2 data measured from the SS. Linear regression analysis was applied to data obtained from five dogs and used to build a three-wavelength algorithm for predicting brain SVO2. In three dogs, SVO2 was varied to test this equation ability to predict SVO2. The standard deviation of differences between measured SVO2 and SVO2 predicted from 31 separate spectra was 3.2%. These predicted values, when regressed against the sampled SVO2, yielded an r value of 0.97. The results demonstrate that during hypoxic hypoxia (HH) it is possible to noninvasively quantify SVO2 with the use of infrared spectroscopy.