Gonadotropin dynamics in patients with gonadal dysgenesis: a model for the study of gonadotropin regulation.
Gonadotropin dynamics in patients with gonadal dysgenesis: a model for the study of gonadotropin regulation.
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性腺发育不全患者的促性腺激素动态：促性腺激素调节研究的模型。
DOI：
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发表时间：
1972
影响因子：
5.8
通讯作者：
R. Rebar
中科院分区：
文献类型：
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作者：
S. Yen;C. Tsai;G. Vandenberg;R. Rebar
在19名12-35岁的性腺发育不全患者中，与绝经前妇女相比，发现血清FSH（10倍）比LH（2-3倍）明显升高。平均血清LH浓度，但不是平均血清FSH浓度，显着低于绝经后妇女。这些患者血清LH和FSH水平的升高是由周期性脉动性垂体放电维持的，平均频率为90分钟。LH和FSH的幅度相当的偶然脉冲是可辨别的，但模式明显不同。E2输注（50 μg/hr × 4 hr）消除了LH释放的脉动性质，并在较小程度上消除了FSH释放，导致循环促性腺激素浓度迅速降低。尽管输注后循环E_2迅速消失，但这种抑制作用平均持续6小时，恢复模式为突然性抑制和持续性抑制。
ABSTRACT In 19 patients with gonadal dysgenesis, 12–35 yr of age, a disproportionally greater elevation of serum FSH (10 times) than LH (2–3 times) was found when compared with the values observed in premenopausal women. The mean serum LH concentration, but not mean serum FSH concentration, was significantly lower than those found in postmenopausal women. The elevated levels of serum LH and FSH in these patients are maintained by periodic pulsatile pituitary discharges with an average frequency of 90 min. Coincidental pulses of LH and FSH of comparable magnitude are discernible, but obvious dissimilarities in the pattern are apparent. E2 infusion (50 μg/hr × 4 hr) abolished the pulsatile nature of LH release and to a lesser degree FSH release which resulted in a rapid reduction in circulating gonadotropin concentrations. Despite the rapid disappearance of circulating E2 following the infusion, the suppression was sustained for an average of 6 hr. The pattern of recovery was composed of an abrupt resumptio...