Computational fluid dynamics as a development tool for rotary blood pumps
Computational fluid dynamics as a development tool for rotary blood pumps
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DOI：
10.1046/j.1525-1594.2001.025005336.x
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发表时间：
2001-05-01
影响因子：
2.4
通讯作者：
Holmes, AJ
中科院分区：
文献类型：
--
作者：
Burgreen, GW;Antaki, JF;Holmes, AJ
计算流体动力学（CFD）开始显著影响生物医学设备的发展，特别是旋转心脏辅助设备。匹兹堡大学麦高恩人工器官开发中心广泛使用CFD作为主要工具来分析和设计具有磁悬浮转子的新型轴流式血泵。使用基于CFD的设计策略开发泵的血液接触表面，该设计策略涉及将Navier-Stokes求解器与参数化几何建模器和高级网格移动技术紧密耦合。基于CFD的剪切诱导溶血的血液损伤模型以及描述血栓形成可能性的替代函数被用来帮助指导设计改进。这种基于CFD的设计方法使得泵的及时开发受到多次几何改进，而无需为每次设计迭代构建昂贵的物理原型。最终改进的泵的物理样机制造和实验分析使用粒子成像流动显示。CFD预测结果与包括压力-流量（H-Q）性能和特定流场特征在内的实验数据具有良好的相关性。据估计，目前基于CFD的设计方法将总体设计时间从几年缩短到几个月。
Computational fluid dynamics (CFD) is beginning to significantly impact the development of biomedical devices, in particular rotary cardiac assist devices. The University of Pittsburgh's McGowan Center for Artificial Organ Development has extensively used CFD as the primary tool to analyze and design a novel axial flow blood pump having a magnetically suspended rotor. The blood-contacting surfaces of the pump were developed using a design strategy based on CFD that involved closely coupling a Navier-Stokes solver to a parameterized geometry modeler and advanced mesh movement techniques. CFD-based blood damage models for shear-induced hemolysis as well as surrogate functions describing thrombosis potential were employed to help guide design improvements. This CFD-based design approach resulted in the timely development of a pump subjected to multiple geometric refinements without building expensive physical prototypes for each design iteration. A physical prototype of the final improved pump was fabricated and experimentally analyzed using particle imaging flow visualization. The CFD predicted results correlated well with the experimental data including pressure-flow (H-Q) performance and specific flow field features. It is estimated that the present CFD-based design approach shortened the overall design time frame from an order of years to months.