Determinants of serum 25 hydroxyvitamin D levels in a nationwide cohort of blacks and non-Hispanic whites
Determinants of serum 25 hydroxyvitamin D levels in a nationwide cohort of blacks and non-Hispanic whites
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DOI：
10.1007/s10552-009-9481-1
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发表时间：
2010-04-01
影响因子：
2.3
通讯作者：
Fraser, Gary E.
中科院分区：
文献类型：
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作者：
Chan, Jacqueline;Jaceldo-Siegl, Karen;Fraser, Gary E.
为一项大型流行病学研究开发预测血清25羟维生素D [s25（OH）D]的算法，该研究的受试者来自大的地理区域，种族多样，年龄、皮肤类型和血液样本采集月份范围广泛。这将允许一个回归校准的方法来确定s25（OH）D水平取代更昂贵的方法收集和分析的血液samples.Questionnaire数据从一个子样本的236个非西班牙裔白人（白人）和209个黑人从广泛分散的基督复临健康研究-2（n = 96，000）被用来开发预测算法的种族分别和合并。以年龄、性别、BMI、皮肤类型、紫外线季节、皮肤区、膳食维生素D总摄入量和阳光暴露因子为自变量的模型分别解释了白色和黑人人群s25（OH）D水平变异的22%和31%（合并时为42%）。根据测定的紫外线辐射确定的紫外线季节和紫外线带产生的模型比季节和纬度的模型具有更高的R（2）。将种族与种族项结合起来并使用测量的紫外线辐射变量比单独分析种族更好地捕捉s25（OH）D水平的方差。
To develop algorithms predicting serum 25 hydroxyvitamin D [s25(OH)D] for a large epidemiological study whose subjects come from large geographic areas, are racially diverse and have a wide range in age, skin types, and month of blood sample collection. This will allow a regression calibration approach to determine s25(OH)D levels replacing the more costly method of collection and analysis of blood samples.Questionnaire data from a subsample of 236 non-Hispanic whites (whites) and 209 blacks from the widely dispersed Adventist Health Study-2 (n = 96,000) were used to develop prediction algorithms for races separately and combined. A single blood sample was collected from each subject, at different times throughout the year.Models with independent variables age, sex, BMI, skin type, UV season, erythemal zone, total dietary vitamin D intake, and sun exposure factor explained 22 and 31% of the variance of s25(OH)D levels in white and black populations, respectively (42% when combined). UV season and erythemal zone determined from measured UV radiation produced models with higher R (2) than season and latitude.Combining races with a term for race and using variables with measured UV radiation capture the variance in s25(OH)D levels better than analyzing races separately.