Strong single-fiber sensory inputs to olfactory cortex: Implications for olfactory coding
Strong single-fiber sensory inputs to olfactory cortex: Implications for olfactory coding
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DOI：
10.1016/j.neuron.2005.12.026
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发表时间：
2006-02-02
期刊：
影响因子：
16.2
通讯作者：
Isaacson, JS
中科院分区：
文献类型：
--
作者：
Franks, KM;Isaacson, JS
嗅觉信息首先由嗅球小球以组合的方式编码，嗅球小球分别代表气味的不同化学特征。然后，这些信息通过嗅球僧帽和簇状（M/T）细胞的轴突传递到梨状（嗅觉）皮层，在那里它被认为是形成气味感受器。然而，哺乳动物嗅觉皮层的感觉信息整合机制尚不清楚。在这里，我们表明，单个M/T细胞可以与皮质锥体细胞的强有力的连接，并符合输入从几个M/T细胞是足以引起尖峰输出。这些结果表明，气味编码是广泛的，分布在嗅觉皮层。
Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form the odor percept. However, mechanisms governing the integration of sensory information in mammalian olfactory cortex are unclear. Here we show that single M/T cells can make powerful connections with cortical pyramidal cells, and coincident input from few M/T cells is sufficient to elicit spike output. These findings suggest that odor coding is broad and distributed in olfactory cortex.