NUTRITIONAL FACTORS AND PANCREATIC-CANCER IN THE FRANCOPHONE COMMUNITY IN MONTREAL, CANADA
NUTRITIONAL FACTORS AND PANCREATIC-CANCER IN THE FRANCOPHONE COMMUNITY IN MONTREAL, CANADA
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DOI：
10.1002/ijc.2910470102
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发表时间：
1991-01-02
影响因子：
6.4
通讯作者：
BOYLE, P
中科院分区：
文献类型：
--
作者：
GHADIRIAN, P;SIMARD, A;BOYLE, P
在一项以人群为基础的胰腺癌饮食危险因素的病例对照研究中，1984年至1988年期间共采访了179例病例和239例对照。 这项研究表明，胰腺癌的风险增加与报告的高水平能量摄入有关。 在对年龄、性别、反应状态、终生吸烟量和能量摄入进行校正后，似乎与总脂肪摄入量相关（最高四分位数相对于最低四分位数的比值比为2.24 [95%置信区间（0.74，6.73）]，特别是饱和脂肪[OR = 4.32，95% CI（1.39，13.7）]。 虽然膳食胆固醇摄入似乎会增加风险，许多微量营养素显然与风险降低有关，但没有统计学意义。 结果与营养因素在胰腺癌病因学中的作用一致。 所涉及的风险之大，强调了对这一主题进行更大规模研究的必要性。
In a population-based case-control study of dietary risk factors for pancreatic cancer, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. This study demonstrated an increased risk of pancreas cancer associated with high levels of reported energy intake. After adjustment for age, sex, response status, lifetime cigarette consumption and energy intake, there appeared to be an association with total fat intake (odds ratio in highest quartile relative to lowest quartile 2.24 [95% Confidence Interval (0.74, 6.73)] and, particularly, saturated fat [OR = 4.32, 95% CI(1.39, 13.7)]. Although dietary cholesterol intake appeared to increase risk and a number of many micro-nutrients were apparently associated with reductions of risk, none were statistically significant. The results are consistent with a role of nutritional factors in the etiology of pancreatic cancer. The magnitude of the risks involved emphasizes the necessity for larger studies of this topic.