A simplified synthesis of the diastereomers of Levuglandin E2
A simplified synthesis of the diastereomers of Levuglandin E2
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DOI：
10.1081/scc-200048945
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发表时间：
2005-01-01
影响因子：
2.1
通讯作者：
Roberts, LJ
中科院分区：
文献类型：
--
作者：
Amarnath, V;Amarnath, K;Roberts, LJ
我们报道了一种合成左旋乌格兰丁E-2的方法，它是一种容易分离的非对映体（15-E-2-异酮）的混合物。其主要特点是其活性醛作为二甲基缩醛的保护，其引入2,2-二甲氧基乙醛，并在几分钟内用蒙脱土K-10去除。该合成可修饰为制备具有稳定同位素或放射性标记的15- e -2-异酮化合物。
We report a synthesis of Levuglandin E-2, as a mixture of easily separable diastereomers (15-E-2-isoketals). The key feature is the protection of its reactive aldehyde as dimethyl acetal, which is introduced with 2,2-dimethoxyethanal and removed in minutes with Montmorillonite K-10. The synthesis could be modified to the preparation of 15-E-2-isoketals with stable isotopes or with radiolabels.