Effects of amlodipine, captopril, and bezafibrate on oxidative milieu in rats with fatty liver
Effects of amlodipine, captopril, and bezafibrate on oxidative milieu in rats with fatty liver
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DOI：
10.1007/s10620-007-9911-4
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发表时间：
2008-03-01
影响因子：
3.1
通讯作者：
Grozovski, Maria
中科院分区：
文献类型：
--
作者：
Ackerman, Zvi;Oron-Herman, Mor;Grozovski, Maria
Oxidative stress may initiate significant hepatocyte injury in subjects with fatty liver. We characterized changes in hepatic oxidative anti-oxidative parameters in rats given a fructose-enriched diet (FED) with and without medications to reduce blood pressure or plasma triglycerides. FED rats had an increase in malondialdehyde (MDA) concentration, a reduction in alpha-tocopherol concentration, a reduction in paraoxonase (PON) activity, an increase in glutathione peroxidase (GSH-Px), and glutathione reductase (GSSG-R) activity. Amlodipine increased PON and GSH-Px, but decreased GSSG-R activity and alpha-tocopherol concentration. Captopril decreased MDA concentration and the activity of both GSH-Px and GSSG-R, but increased alpha-tocopherol concentration and PON activity. Bezafibrate increased alpha-tocopherol concentration and PON activity, but decreased the activity of GSSG-R. Animals with fatty liver exhibit an increase in peroxidative stress but also a defect in anti-oxidative pathways. Drugs administered to treat hypertension and hypertriglyceridemia could lead to a variety of changes in the hepatic oxidative, anti-oxidative milieu.
