Spontaneous polarization and cell guidance on asymmetric nanotopography
Spontaneous polarization and cell guidance on asymmetric nanotopography
复制标题
非对称纳米形貌的自发极化和细胞导向
DOI：
10.1038/s42005-022-00889-0
复制
发表时间：
2022-05-11
影响因子：
5.5
通讯作者：
Losert, Wolfgang
中科院分区：
文献类型：
--
作者：
Herr, Corey;Winkler, Benjamin;Losert, Wolfgang
Asymmetric nanotopography with sub-cellular dimensions has recently demonstrated the ability to provide a unidirectional bias in cell migration. The details of this guidance depend on the type of cell studied and the design of the nanotopography. This behavior is not yet well understood, so there is a need for a predictive description of cell migration on such nanotopography that captures both the initiation of migration, and the way cell migration evolves. Here, we employ a three-dimensional, physics-based model to study cell guidance on asymmetric nanosawteeth. In agreement with experimental data, our model predicts that asymmetric sawteeth lead to spontaneous motion. Our model demonstrates that the nanosawteeth induce a unidirectional bias in guidance direction that is dependent upon actin polymerization rate and sawtooth dimensions. Motivated by this model, an analysis of previously reported experimental data indicates that the degree of guidance by asymmetric nanosawteeth increases with the cell velocity.Asymmetric nanotopography biases unidirectional cell migration, yet the underpinning molecular determinants are still unclear. The authors use a three-dimensional model to demonstrate that nanosawteeth induce actin-mediated migration directionality, which is dependent on the cell velocity.
