beta-Endorphin-(1-27) inhibits the spinal beta-endorphin-induced release of Met-enkephalin.
beta-Endorphin-(1-27) inhibits the spinal beta-endorphin-induced release of Met-enkephalin.
复制标题
beta-Endorphin-(1-27) 抑制脊髓 β-内啡肽诱导的 Met-脑啡肽释放。
DOI：
10.1111/j.1399-3011.1986.tb01033.x
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Li,CH
中科院分区：
文献类型：
--
作者：
Tseng,LF;Li,CH
采用氨基甲酸乙酯麻醉大鼠，采用鞘内灌注技术研究了脑室β -内啡肽（1-27）对脑室β -内啡肽诱导的Met -脑啡肽脊髓释放的影响。脑室内注射15 μg的β -内啡肽可以从脊髓中释放出Met -脑啡肽。β -内啡肽（1-27）60 μg可显著降低β -内啡肽诱导的Met - enkephalin释放。注射β -内啡肽（1-27）本身不引起Met -脑啡肽的释放。这一发现与先前报道的β -内啡肽（1-27）抑制β -内啡肽引起的镇痛一致。
The effect of intraventricular β‐endorphin‐(1–27) on the spinal release of Met‐enkephalin induced by intraventricular β‐endorphin was studied using the intrathecal superfusion technique in urethane anesthetized rats. Intraventricular injection of β‐endorphin at a dose of 15 μg released Met‐enkephalin from the spinal cord. This release of Met‐enkephalin induced by β‐endorphin was significantly reduced by β‐endorphin‐(1–27), 60 μg, injected intraventricularly. Injection of β‐endorphin (1–27) itself did not cause any release of Met‐enkephalin. The finding is in line with the previous report that β‐endorphin (1–27) inhibited the analgesia induced by β‐endorphin.