Colonization and infection by Helicobacter pylori in humans
Colonization and infection by Helicobacter pylori in humans
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DOI：
10.1111/j.1523-5378.2007.00574.x
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发表时间：
2007-11-01
期刊：
影响因子：
4.4
通讯作者：
Andersen, Leif Percival
中科院分区：
文献类型：
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作者：
Andersen, Leif Percival
当幽门螺杆菌到达人胃时，它可能穿透粘蛋白层并粘附于胃上皮细胞，或者它可能穿过胃而不定植于粘膜。在本文中，定殖过程和随后的免疫反应将简要描述。脲酶的产生是H. pylori以在细菌周围建立pH中性的微环境。鞭毛使细菌能够移动，H。幽门螺杆菌使其有可能穿透粘蛋白层，在那里它与胃上皮细胞接触。H.幽门螺杆菌含有几种使其能够粘附于上皮细胞的粘附素。这种粘附激活IL-8，其与细菌抗原一起吸引多形细胞和单核细胞并引起急性胃炎。抗原呈递细胞激活淋巴细胞和其他单核细胞，这些细胞被吸引到发炎的粘膜，引起慢性浅表性胃炎并启动细胞毒性或抗原产生Th应答。感染是在初次接触H.幽门。在这种最初的定殖之后，发生许多化学、生物化学和免疫反应，这些反应在感染的进展和疾病的发展中是重要的。
When Helicobacter pylori arrives in the human stomach, it may penetrate the mucin layer and adhere to the gastric epithelial cells or it may pass through the stomach without colonizing the mucosa. In this paper, the colonization process and the ensuing immunological response will be briefly described. Urease production is necessary for H. pylori to establish a pH-neutral microenvironment around the bacteria. The flagella enable the bacteria to move and the shape of H. pylori makes it possible to penetrate the mucin layer where it comes into contact with the gastric epithelial cells. H. pylori contains several adhesins that enable it to adhere to the epithelial cells. This adherence activates IL-8 which, together with bacterial antigens, attracts polymorphs and monocytes and causes acute gastritis. Antigen-presenting cells activate lymphocytes and other mononuclear cells that are attracted to the inflamed mucosa, causing chronic superficial gastritis and initiating a cytotoxic or an antigen-producing Th response. The infection is established within a few weeks after the primary exposure to H. pylori. After this initial colonization, many chemical, biochemical, and immunologic reactions take place that are of importance in the progress of the infection and the development of disease.