Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease
Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease
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DOI：
10.1097/01.wnr.0000187637.20771.a0
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发表时间：
2005-11-28
期刊：
影响因子：
1.7
通讯作者：
Gill, SS
中科院分区：
文献类型：
--
作者：
Plaha, P;Gill, SS
步态障碍和姿势不稳定是特发性帕金森病的一些最致残的症状，并且在疾病晚期可以抵抗药物和手术治疗。我们将双侧深部脑刺激电极植入两例晚期帕金森病患者的桥脚核。我们首次证明，低频（20-25赫兹）刺激该核显著改善了“开”和“关”药物状态下的步态功能障碍和姿势不稳定。他们的统一帕金森病评定量表总分提高了53%，运动评分提高了57%。没有观察到手术或刺激相关的并发症。如果这些发现在更多的患者中得到重复，那么桥脚核刺激可能提供减轻这些致残和其他治疗抵抗性晚期帕金森病症状的手段。
Gait disturbance and postural instability are some the most disabling symptoms of idiopathic Parkinson's disease and in late stage disease can be resistant to both medical and surgical therapies. We implanted bilateral deep brain stimulation electrodes into the pedunculopontine nucleus in two patients with advanced Parkinson's disease. We demonstrate for the first time that low frequency (20-25 Hz) stimulation of this nucleus significantly improves gait dysfunction and postural instability in both the 'on' and 'off' medication states. Their combined total Unified Parkinson's Disease Rating Scale score improved by 53% and motor score by 57%. No procedure or stimulation-related complications were observed. If these findings are replicated in a larger number of patients, pedunculopontine nucleus stimulation may provide the means to alleviate these disabling and otherwise treatment-resistant symptoms of advanced Parkinson's disease.