HIV protease inhibitors alter innate immune response signaling to double-stranded RNA in oral epithelial cells: implications for immune reconstitution inflammatory syndrome?
HIV protease inhibitors alter innate immune response signaling to double-stranded RNA in oral epithelial cells: implications for immune reconstitution inflammatory syndrome?
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DOI：
10.1097/qad.0b013e32833f4022
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发表时间：
2010-10-23
期刊：
影响因子：
3.8
通讯作者：
Miller, Craig S.
中科院分区：
文献类型：
--
作者：
Danaher, Robert J.;Kaetzel, Charlotte S.;Miller, Craig S.
在这项研究中，几种HIV蛋白酶抑制剂改变了病毒相关的双链RNA(DsRNA)刺激的先天免疫反应。最有效的白介素8表达诱导剂洛比那韦也抑制dsRNA诱导的单核细胞趋化蛋白1的表达。进一步的分析表明，核因子-kappa B是洛匹那韦诱导IL-8所必需的。这些发现表明，蛋白酶抑制剂，如洛匹那韦，以一种可能影响口腔上皮免疫(重建)炎症反应的方式，对先天免疫信号进行不同程度的失调。
In this investigation, several HIV protease inhibitors altered the virally associated, double-stranded RNA (dsRNA)-stimulated, innate immune response. Lopinavir, the most potent inducer of interleukin (IL)-8 expression, also inhibited dsRNA-induced monocyte chemotactic protein 1 expression. Further analyses demonstrated that nuclear factor-kappa B is required for lopinavir's induction of IL-8. These findings demonstrate that protease inhibitors, such as lopinavir, differentially dysregulate innate immune signaling in a manner that could affect immune (reconstitution) inflammatory responses in oral epithelium.