CD8 T cell recall responses are regulated by the tissue tropism of the memory cell and pathogen
CD8 T cell recall responses are regulated by the tissue tropism of the memory cell and pathogen
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DOI：
10.4049/jimmunol.177.10.6738
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发表时间：
2006-11-15
影响因子：
4.4
通讯作者：
Lefrancois, Leo
中科院分区：
文献类型：
--
作者：
Klonowski, Kimberly D.;Marzo, Amanda L.;Lefrancois, Leo
记忆性CD 8 T细胞是否能在非淋巴组织中重新激活尚不清楚。使用缺乏脾脏，淋巴结，或两者兼而有之的小鼠，我们表明，次级T细胞反应，但不是稳态维持记忆细胞，需要淋巴组织。而主要和次要的CD 8 T细胞反应水泡性口炎病毒感染的淋巴结依赖性，单核细胞增生李斯特菌感染的反应主要是在脾脏驱动。记忆细胞亚群的再激活也受到响应群体和病原体的位置的调节。因此，CD 62 L（低）效应记忆T细胞（T-EM）细胞的反应几乎与CD 62 L（高）中枢记忆T细胞（T-CM）和T-CM细胞一样。单核细胞增多症感染，并且两个子集产生次级记忆细胞的相等群体。相比之下，T-CM细胞，而不是T-EM细胞，安装一个强大的响应水泡性口炎病毒感染。T-CM和T-EM细胞也需要淋巴组织来产生回忆反应，而骨髓对这两个亚群的反应没有显著贡献。我们的研究结果表明，感染剂的特性和记忆细胞的迁移偏好决定了次级淋巴组织对感染的回忆反应的要求。
Whether memory CD8 T cells can be reactivated in nonlymphoid tissues is unclear. Using mice lacking the spleen, lymph nodes, or both, we show that the secondary T cell response, but not homeostatic maintenance of memory cells, required lymphoid tissue. Whereas primary and secondary CD8 T cell responses to vesicular stomatitis virus infection were lymph node dependent, responses to Listeria monocytogenes infection were driven primarily in the spleen. Memory cell subset reactivation was also regulated by location of the responding population and the pathogen. Thus, CD62L(low) effector memory T cells (T-EM) cells responded nearly as well as CD62L(high) central memory T cells (T-CM) and T-CM cells after L. monocytogenes infection, and both subsets generated equivalent populations of secondary memory cells. In contrast, T-CM cells, but not T-EM cells, mounted a robust response to vesicular stomatitis virus infection. T-CM and T-EM cells also required lymphoid tissue to mount recall responses, and the bone marrow did not contribute significantly to the response of either subset. Our findings indicated that characteristics of the infectious agent and the migratory preferences of memory cells dictated the secondary lymphoid tissue requirement for the recall response to infection.