Apolipoprotein A5 gene IVS3+G476A allelic variant confers susceptibility for development of ischemic stroke
Apolipoprotein A5 gene IVS3+G476A allelic variant confers susceptibility for development of ischemic stroke
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DOI：
10.1253/circj.72.1065
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发表时间：
2008-07-01
影响因子：
3.3
通讯作者：
Melegh, Bela
中科院分区：
文献类型：
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作者：
Maasz, Anita;Kisfali, Peter;Melegh, Bela
研究背景载脂蛋白A5（apolipoprotein A5，APOA 5）基因T-1131 C、T1259 C和IVS 3 + G476 A三个突变体在缺血性脑卒中发病中的作用。378例患者和131例无卒中对照受试者的大血管和混合亚组。在所有卒中组和对照组中，携带-1131C，1259 C，IVS 3 + 476 A等位基因的受试者中发现甘油三酯水平升高。-1131C和IVS 3 + 476 A等位基因，而不是T1259 C变异体，在所有卒中亚组中显示出显著的积累。经年龄、性别、体重指数、总胆固醇水平、缺血性心脏病、高血压、糖尿病、吸烟和饮酒习惯校正后的Logistic回归分析显示，IVS 3 + 476 A等位基因是卒中的独立易感因素（小血管优势比：4.748;大血管优势比：3.905;混合优势比：2.926;总体优势比：3.644，95%置信区间; p
Background T-1131C, T1259C and IVS3+G476A are naturally occurring variants of the apolipoprotein A5 (APOA5) gene and their possible impact on the development of ischemic Stroke was investigated in the present study.Methods and Results PCR-RFLP assays were used to determine the distributions of the APOA5 alleles in small-vessel, large-vessel and mixed subgroups of 378 patients and in 13 1 stroke-free control subjects. Increased triglyceride levels were found in subjects carrying -1131C, 1259C, IVS3+476A alleles in all stroke groups and in the controls. The -1131C and IVS3+476A alleles, but not the T1259C variant, showed significant accumulation in all stroke subgroups. Logistic regression analysis adjusted for age, gender, body mass index, total cholesterol level, ischemic heart disease, hypertension, diabetes mellitus, smoking-and drinking habits revealed that the IVS3+476A allele represents independent susceptibility factor for stroke (odds ratio for small-vessel: 4.748; large-vessel: 3.905; mixed: 2.926; overall: 3.644 at 95% confidence interval; p