A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2
A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2
复制标题
DOI：
10.1111/febs.15375
复制
发表时间：
2020-06-16
期刊：
影响因子：
5.4
通讯作者：
Clements, Thomas P.
中科院分区：
文献类型：
--
作者：
Atzrodt, Cassandra L.;Maknojia, Insha;Clements, Thomas P.
人类冠状病毒SARS-CoV-2毒株的出现使世界陷入了一场新的大流行之中。在人体内，该病毒导致COVID-19，这是一种以呼吸短促、发烧和肺炎为特征的疾病，对脆弱的个体来说可能是致命的。SARS-CoV-2具有过去人类冠状病毒的特征，与导致SARS疾病的SARS-CoV具有密切的基因组相似性。与这些相关的冠状病毒一样，SARS-CoV-2通过吸入飞沫和与污染表面的相互作用传播。在世界各地，实验室正在开发该病毒的候选疫苗-美国和英国正在进行疫苗试验-并考虑各种可能的治疗和预防药物。在这里，我们通过分析其病毒学，流行病学和传播模式，同时检查当前的测试程序和可能的治疗方法的进展，通过药物和疫苗，提供了一个概述SARS-CoV-2。
The emergence of the SARS-CoV-2 strain of the human coronavirus has thrown the world into the midst of a new pandemic. In the human body, the virus causes COVID-19, a disease characterized by shortness of breath, fever, and pneumonia, which can be fatal in vulnerable individuals. SARS-CoV-2 has characteristics of past human coronaviruses, with close genomic similarities to SARS-CoV, the virus that causes the disease SARS. Like these related coronaviruses, SARS-CoV-2 is transmitted through the inhalation of droplets and interaction with contaminated surfaces. Across the world, laboratories are developing candidate vaccines for the virus - with vaccine trials underway in the United States and the United Kingdom - and considering various drugs for possible treatments and prophylaxis. Here, we provide an overview of SARS-CoV-2 by analyzing its virology, epidemiology, and modes of transmission while examining the current progress of testing procedures and possible treatments through drugs and vaccines.