Hydrogen sulfide in ageing, longevity and disease.
Hydrogen sulfide in ageing, longevity and disease.
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DOI：
10.1042/bcj20210517
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发表时间：
2021-10-15
期刊：
影响因子：
--
通讯作者：
Selman C
中科院分区：
文献类型：
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作者：
Wilkie SE;Borland G;Carter RN;Morton NM;Selman C
硫化氢（H2S）调节许多生物过程，包括衰老。最初被认为是一种危险的有毒气体，现在人们认识到，H2S是在整个分类群中内源性产生的，是促进长寿和改善晚年健康的过程的关键介质。在这篇综述中，我们认为在健康和疾病的背景下，这种气体信号分子的理解的关键发展，讨论潜在的机制，通过H2S可以影响过程的核心老化和突出的新H2S为基础的治疗方法的出现。我们还考虑了可能阻碍这种疗法发展的主要挑战。
Hydrogen sulfide (H2S) modulates many biological processes, including ageing. Initially considered a hazardous toxic gas, it is now recognised that H2S is produced endogenously across taxa and is a key mediator of processes that promote longevity and improve late-life health. In this review, we consider the key developments in our understanding of this gaseous signalling molecule in the context of health and disease, discuss potential mechanisms through which H2S can influence processes central to ageing and highlight the emergence of novel H2S-based therapeutics. We also consider the major challenges that may potentially hinder the development of such therapies.