Calcium Alginate Gel as a Biocompatible Material for Endovascular Arteriovenous Malformation Embolization: Six-month Results in an Animal Model
Calcium Alginate Gel as a Biocompatible Material for Endovascular Arteriovenous Malformation Embolization: Six-month Results in an Animal Model
复制标题
海藻酸钙凝胶作为生物相容性材料用于血管内动静脉畸形栓塞：动物模型的六个月结果
作者：
T. Becker;M. Preul;W. Bichard;D. Kipke;C. McDougall
目的：我们试图扩大海藻酸钙作为脑动静脉畸形（AVM）动物模型栓塞剂的评估。本研究的目的是评估海藻酸钙在存活1至6个月的AVM猪模型中的长期生物相容性和稳定性。方法：猪模型包括颈动脉-颈静脉吻合术，以将血流重定向至奇异网（RM），从而模拟AVM的血流。从双腔或同心管微导管中注射藻酸盐和反应组分氯化钙，以形成RM供血血管和RM下部的闭塞。结果：血管造影和组织学证实，9只猪中有8只的RM供血血管完全闭塞长达6个月。RM的上级部分和Willis环的血流保持开放。在随访血管造影或Willis环组织学制备中未发现下游藻酸钙凝胶的证据。在1个月时注意到对藻酸盐凝胶的轻微生物活性反应，但未观察到退行性或炎症反应。在6个月时，藻酸盐周围存在中度纤维组织，其进一步封闭了RM栓塞区域的血流。结论：在6个月的时间内，藻酸钙是一种有效的血管内闭塞材料，可阻断RM下部的血流。慢性AVM模型验证了海藻酸钙的长期稳定性和生物相容性。
OBJECTIVE:We sought to expand our assessment of calcium alginate as an embolic agent in an animal model of a cerebral arteriovenous malformation (AVM). The objective of this study was to assess the long-term biocompatibility and stability of calcium alginate in AVM swine models that survived from 1 to 6 months. METHODS:The swine model included a carotid-jugular anastomosis to redirect flow to the rete mirabile (RM), thereby simulating flow to an AVM. Alginate and the reactive component, calcium chloride, were injected from double-lumen or concentric-tube microcatheters to form an occlusion of the RM feeding vessel and the inferior portion of the RM. RESULTS:Angiography and histology verified complete occlusion of the RM feeding vessel for up to 6 months in eight of nine swine. Blood flow remained open to the superior portion of the RM and the circle of Willis. No evidence of downstream calcium alginate gel was seen in the follow-up angiograms or the histological preparations of the circle of Willis. A minor bioactive response to the alginate gel was noted at 1 month, yet no degenerative or inflammatory response was seen. At 6 months, there was moderate fibrous tissue around the alginate, which further sealed off flow to the embolized areas of the RM. CONCLUSION:Over a period of 6 months, calcium alginate was an effective endovascular occlusion material that blocked blood flow to the inferior portion of the RM. The chronic AVM model verified the long-term stability and biocompatibility of calcium alginate.
实验性动静脉畸形的经静脉血流动力学评估。
影响因子：
8.3
作者：
Murayama,Y;Massoud,TF;Viñuela,F
通讯作者：
Viñuela,F
猪模型慢性动静脉畸形的组织病理学特征：初步研究。
DOI：
--
发表时间：
2000
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Massoud,TF;Vinters,HV;Chao,KH;Viñuela,F;Jahan,R
通讯作者：
Jahan,R