The response to the intramuscular implantation of pure metals.
The response to the intramuscular implantation of pure metals.
复制标题
对肌肉内植入纯金属的反应。
DOI：
10.1016/0142-9612(81)90085-5
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发表时间：
1981
期刊：
影响因子：
14
通讯作者：
D. Williams
中科院分区：
文献类型：
--
作者：
A. McNamara;D. Williams
将五种高纯度金属钴、镍、铜、铝和铅的圆盘植入大鼠肌肉内，并在组织学上观察长达52周的反应。观察到每种金属的可重现但不同的响应。无论何时发生腐蚀，如铜、镍和一些钴样本，植入物都会松动。在没有腐蚀的情况下，植入物被牢固地固定在更封闭的囊内。在铅中观察到最小反应，这意味着正常情况下有毒金属不一定会在植入时诱导过度反应。然而，有证据表明，某些金属会引起免疫反应，而某些金属，特别是铜和镍，似乎会使宿主更容易感染疾病。植入物似乎对直接血管系统有深远的影响，能够以与细菌相同的方式引起延长的多形核反应，与不同数量的含铁血黄素巨噬细胞相关，但与巨细胞无关。这些动物似乎能够处理手术中引入的细菌，而不会受到金属的阻碍。
Discs of five high-purity metals, cobalt, nickel, copper, aluminium and lead have been implanted intramuscularly in rats and the response observed histologically for period up to 52 weeks. A reproducible but different response was observed with each metal. Whenever corrosion occurred, as with copper, nickel and some cobalt specimens, the implants became loose. In the absence of corrosion, the implants were firmly held within a more confined capsule. A minimal response was seen with lead, implying normally toxic metals do not necessarily induce excessive responses on implantation. Evidence was found, however, that some metals elicit an immune response whilst some, especially copper and nickel appear to render the host more susceptible to disease. The implants appear to have a profound effect on the immediate vasculature, are able to cause a prolonged polymorphonuclear response in the same way as bacteria, are associated with varying amounts of haemosiderin laden macrophages but not with giant cells. The animals appear to be able to deal with bacteria introduced at surgery without hindrance from the metal.