Evolution of bacterial diversity and the origins of modularity
Evolution of bacterial diversity and the origins of modularity
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DOI：
10.1016/j.resmic.2004.01.011
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发表时间：
2004-06-01
影响因子：
2.6
通讯作者：
Cooper, TE
中科院分区：
文献类型：
--
作者：
Rainey, PB;Cooper, TE
所有生物体的一个特征是模块化组织：一组基因以某种方式相互作用的趋势，以限制属于不同功能复合体的特征之间的多效性影响的程度。虽然模块化对可变性进化的影响已经讨论了很多，但进化的起源仍然不清楚。在这里，我们开发了一个模型，特别参考了细菌的信号转导级联，该模型预测，在面临生态机会和横向基因转移时，选择将有利于模块化基因组结构，因为这种结构最大限度地减少了与容纳潜在有益的外来DNA相关的多效性效应。(C)2004年爱思唯尔公司。版权所有。
A characteristic feature of all organisms is modular organisation: the tendency for groups of genes to interact in such a way as to limit the extent of pleiotropic effects among characters belonging to different functional complexes. While the implications of modularity for the evolution of variability have been much discussed the evolutionary origins remain obscure. Here we develop a model, with special reference to signal transduction cascades of bacteria, which predicts that in the face of ecological opportunity and lateral gene transfer, selection will favour modular genome architectures because such architectures minimise the pleiotropic effects associated with accommodation of potentially beneficial foreign DNA. (C) 2004 Elsevier SAS. All rights reserved.