Noise trauma in the aetiology of acoustic neuromas in men in Los Angeles County, 1978-1985.
Noise trauma in the aetiology of acoustic neuromas in men in Los Angeles County, 1978-1985.
复制标题
1978 - 1985年，洛杉矶县男性声学神经瘤病因的噪音创伤。
DOI：
10.1038/bjc.1989.163
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发表时间：
1989-05
影响因子：
8.8
通讯作者：
Henderson, B E
中科院分区：
文献类型：
--
作者：
Preston-Martin, S;Thomas, D C;Wright, W E;Henderson, B E
本研究的目的是调查职业和其他脑肿瘤危险因素是否与男性听神经瘤（AN）的发展有关。对86例AN患者和86例邻居对照进行了访谈。在10年或更长的时间内，诊断的情况下，比对照组有一个工作，涉及暴露于非常响亮的噪音，噪音暴露是由一个盲目的审查工作历史和链接到国家职业危害调查数据库（比值比（OR）= 2.2，95%置信区间（CI）= 1.12，4.67）。剂量-反应分析显示，在诊断前10年内，暴露于极强噪声的工作年数（趋势P = 0.02）的风险增加，暴露20年或更长时间的OR为13.2（CI = 2.01，86.98）。我们认为，本研究中将噪音确定为风险因素的发现支持了机械创伤可能导致肿瘤发生的假设。
The aim of this study was to investigate whether occupational and other suggested brain tumour risk factors relate to the development of acoustic neuromas (AN) in men. Responses to interviews were compared for 86 AN patients and 86 neighbourhood controls. During the period 10 or more years before the year of diagnosis of the case, more cases than controls had a job involving exposure to extremely loud noise; noise exposure was determined by a blinded review of job histories and linkage to the National Occupational Hazards Survey data base (odds ratio (OR) = 2.2, 95% confidence interval (CI) = 1.12, 4.67). A dose-response analysis showed an increase in risk related to number of years of job exposure to extremely loud noise (P for trend = 0.02) with an OR of 13.2 (CI = 2.01, 86.98) for exposure for 20 or more years during the period up to 10 years before diagnosis. We propose that the findings in this study which identify noise as a risk factor support the hypothesis that mechanical trauma may contribute to tumorigenesis.