Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects
Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects
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DOI：
10.1161/01.cir.0000060496.23144.a7
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发表时间：
2003-04-15
期刊：
影响因子：
37.8
通讯作者：
Fliser, D
中科院分区：
文献类型：
--
作者：
Kielstein, JT;Bode-Böger, SM;Fliser, D
背景-一氧化氮（NO）的减少被认为是与年龄相关的肾血管紧张度和血压升高的原因。我们评估了内源性NO合酶抑制剂不对称二甲基精氨酸（ADMA）的血药浓度以及肾脏血流动力学，比较年轻人和老年人。（n=24，13名男性，25+/-1岁）和老年人（n=24，13例男性，69 ± 2岁）健康受试者和老年原发性高血压受试者（n=24，13名男性，70+/-2岁）。方法和结果：血浆ADMA浓度和肾血管阻力（RVR）显著高于（P
Background-Reduced availability of nitric oxide (NO) is thought to contribute to the age-associated increase of renovascular tone and blood pressure. We assessed blood concentrations of the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA) as well as renal hemodynamics, comparing young (n=24, 13 men, 25+/-1 years) and elderly (n=24, 13 men, 69+/-2 years) healthy subjects and elderly subjects with essential hypertension (n=24, 13 men, 70+/-2 years).Methods and Results-Plasma ADMA concentration and renovascular resistance (RVR) were significantly higher (P