Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: Results of the US upper gastrointestinal study
Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: Results of the US upper gastrointestinal study
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DOI：
10.1016/s1542-3565(05)00153-9
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发表时间：
2005-06-01
影响因子：
12.6
通讯作者：
Revicki, DA
中科院分区：
文献类型：
--
作者：
Camilleri, M;Dubois, D;Revicki, DA
背景与目的：本研究在具有全国代表性的美国样本中检查了上胃肠道（GI）症状的患病率和症状分组，并确定了对残疾天数的影响。方法：对21,128名成年人进行电话调查，包括在过去3个月内出现上消化道症状的问题。受访者被分为有症状（即每月报告一次胃肠道症状）或无症状。调查的问题包括错过的工作、休闲活动或家庭活动日。通过因子分析确定症状分组，并根据这些症状分组采用聚类分析将受访者划分为不同的组。结果：患病率平均为1。在过去3个月内出现或更多上消化道症状的患者占44.9%。过去3个月最常见的症状是早期饱腹感、胃灼热和餐后饱腹感。因子分析确定了4种症状组：(1)胃灼热/反流；(2)恶心/呕吐;(3)腹胀/腹痛；(4)早饱/食欲不振。确定了五个应答组；最大的群体主要是早期饱腹/饱腹（44%）和胃食管反流疾病样症状（28%）。两个小集群反映恶心和呕吐（7%）和异质性症状（4%）。有症状的应答者报告的工作、休闲和家庭活动天数明显多于无症状应答者(P
Background & Aims: This study examined the prevalence of upper gastrointestinal (GI) symptoms and symptom groupings and determined impact on disability days in a nationally representative US sample. Methods: A telephone survey of 21,:128 adults was conducted including questions about the presence of upper GI symptoms during the past 3 months. Respondents were categorized as symptomatic (ie, reported GI symptoms once per month) or asymptomatic. The survey included questions about missed work, leisure activity, or household activity days. Symptom groupings were identified by using factor analysis, and cluster analysis was used to assign respondents into distinct groups on the basis of these symptom groupings. Results: The prevalence of an average of 1. or more upper GI symptoms during the past 3 months was 44.9%. The most common symptoms experienced during the past 3 months were early satiety, heartburn, and postprandial fullness. Factor analysis identified 4 symptom groupings: (1) heartburn/ regurgitation; (2) nausea/vomiting; (3) bloating/abdominal pain; and (4) early satiety/loss of appetite. Five respondent clusters were identified; the largest clusters were primarily early satiety/fullness (44%) and gastroesophageal reflux disease-like symptoms (28%). Two small clusters reflected nausea and vomiting (7%) and a heterogeneous symptom profile (4%). Symptomatic respondents reported significantly more missed work, leisure, and household activity days than asymptomatic respondents (all P