Evaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping
Evaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping
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DOI：
10.1177/0271678x18764829
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发表时间：
2019-08
影响因子：
6.3
通讯作者：
M. Miyata;S. Kakeda;K. Kudo;S. Iwata;Yoshiya Tanaka;Yi Wang;Y. Korogi
中科院分区：
文献类型：
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作者：
M. Miyata;S. Kakeda;K. Kudo;S. Iwata;Yoshiya Tanaka;Yi Wang;Y. Korogi
本研究的目的是评估系统性红斑狼疮（SLE）患者mri定量易感性图谱（QSM）中氧提取分数（OEF）的变化，并确定QSM-OEF是否与SLE疾病活动性相关。我们招募了42名SLE患者和20名健康受试者（HS），他们在常规脑MRI上没有病变。采用SLE疾病活动性指数（SLEDAI）评估疾病活动性。对于QSM- oef的测量，使用灌注失配分析仪软件程序分析QSM数据。计算Spearman或Pearson相关系数，并通过多元线性回归分析确定独立预测因子。SLE患者QSM-OEF明显高于HS患者（51.3±10.1比40.5±3.7,p < 0.001）。QSM-OEF与SLEDAI和神经精神症状（NPS）评分呈正相关（ρ = 0.663, p < 0.001; ρ = 0.340, p = 0.028）。多元线性回归分析显示，SLEDAI和NPS与QSM-OEF独立相关（标准化β = 0.426, p = 0.016，标准化β = 6.148, p = 0.029）。在SLE患者中，QSM-OEF与疾病活动性相关，这可能预测SLE患者卒中风险的增加。
The purposes of this study are to assess the oxygen extraction fraction (OEF) changes on MRI-based quantitative susceptibility mapping (QSM) in systemic lupus erythematosus (SLE) patients and to determine whether QSM-OEF is associated with disease activity in SLE. We enrolled 42 SLE patients and 20 healthy subjects (HS) who had no pathologies on conventional brain MRI. Disease activity was assessed using SLE Disease Activity Index (SLEDAI). For the measurement of QSM-OEF, QSM data were analysed using the Perfusion Mismatch Analyzer software program. Spearman's or Pearson's correlation coefficients were calculated, and independent predictors were identified through a multiple linear regression analysis. QSM-OEF was significantly higher in SLE than that in HS (51.3 ± 10.1 vs. 40.5 ± 3.7, p < 0.001). QSM-OEF was positively correlated with SLEDAI and the presence of neuropsychiatric symptom (NPS) scores (ρ = 0.663, p < 0.001 and ρ = 0.340, p = 0.028). At multiple linear regression analysis, SLEDAI and NPS were independently associated with QSM-OEF (standardized β = 0.426, p = 0.016 and standardized β = 6.148, p = 0.029). In the SLE patients, QSM-OEF is associated with disease activity, which might predict an increased risk of stroke in SLE.