Hormones in saliva: mode of entry and consequent implications for clinical interpretation.
Hormones in saliva: mode of entry and consequent implications for clinical interpretation.
复制标题
唾液中的激素：进入方式及其对临床解释的影响。
作者：
R. Vining;R. McGinley;R. G. Symons
唾液中激素的检测将比血液中的检测更方便，但目前还没有关于激素进入唾液的途径的信息，这些信息可以为此类检测的临床价值提供洞察。我们研究了各种荷尔蒙进入唾液的方式。结果表明，未结合类固醇通过唾液腺细胞扩散进入唾液，它们在唾液中的浓度并不取决于唾液产生的速度。结合类固醇通过腺泡细胞之间的紧密连接通过“超滤”进入唾液，它们在唾液中的浓度高度依赖于流速。甲状腺激素和绒毛膜促性腺激素通过超滤途径或被血浆或牙周液污染进入唾液。我们得出结论，唾液中非结合类固醇的浓度可以有效地反映血浆中游离(非蛋白结合)类固醇的浓度。相反，唾液中结合类固醇、甲状腺激素和蛋白质激素(如绒毛膜促性腺激素)的浓度可能不能以任何临床有用的方式反映它们在血浆中的浓度。
Assay of hormones in saliva would be more convenient than assay in blood, but there is no information on the route by which hormones enter saliva, information that would provide insight into the clinical value of such assays. We have examined the mode of entry of various hormones into saliva. The results suggest that unconjugated steroids enter saliva by diffusing through the cells of the salivary glands and that their concentration in saliva does not depend on the rate of saliva production. Conjugated steroids enter saliva via "ultrafiltration" through the tight junctions between the acinar cells, and their concentration in saliva is highly flow-rate dependent. Thyroxin and choriogonadotropin enter saliva via the ultrafiltration route or by contamination of the saliva by plasma or gingival fluid. We conclude that the salivary concentration of unconjugated steroids may usefully reflect the concentration of free (nonprotein-bound) steroids in plasma. Conversely, the concentration of conjugated steroids, thyroxin, and protein hormones such as choriogonadotropin in saliva probably does not reflect their concentration in plasma in any clinically useful way.