Effects of Ginkgo bioba extract on renal cytochrome C and mitochondrial calcium levels in diabetic rats
Effects of Ginkgo bioba extract on renal cytochrome C and mitochondrial calcium levels in diabetic rats
复制标题
DOI：
--
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Wang Fangfang
中科院分区：
文献类型：
--
作者：
Wang Fangfang
目的：目的：观察银杏叶提取物（GBE）对糖尿病大鼠肾脏细胞色素C和线粒体钙水平的影响。方法：将30只雄性Wistar大鼠随机分为正常组、模型组和GBE组，模型组和GBE组大鼠经腔静脉一次性注射2%链脲佐菌素（STZ），采用张俊田改良法测定细胞色素C水平，火焰原子吸收法测定线粒体钙水平。结果：银杏叶提取物组细胞色素C和线粒体钙含量明显低于模型组（P0.05）。结论：银杏叶提取物可减少细胞色素C的释放，维持线粒体钙稳态。
Objective: To observe the effects of Ginkgo bioba extract (GBE) on renal cytochrome C and mitochondrial calcium levels in diabetic rats.Methods:Thirty male Wistar rats were randomly divided into 3 groups(normal group;model group and GBE group),the model and GBE group rats were injected 2% STZ once through the vena cava.The cytochrome C level was measured by using Zhangjuntian's modified methods,and the mitochondrial calcium level was detected by flame atom absorption. Results:The levels of cytochrome C and mitochondrial calcium in GBE group were significantly lower than those in model group(P0.05).Conclusion:GBE can reduce the release of cytochrome C and maintain mitochondrial calcium homeostasis.