Constructing the suprachiasmatic nucleus: a watchmaker's perspective on the central clockworks.
Constructing the suprachiasmatic nucleus: a watchmaker's perspective on the central clockworks.
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DOI：
10.3389/fnsys.2015.00074
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发表时间：
2015
影响因子：
3
通讯作者：
Blackshaw S
中科院分区：
文献类型：
--
作者：
Bedont JL;Blackshaw S
昼夜节律系统将生物体的行为调色板限制在与其生态位相适应的太阳日部分。哺乳动物昼夜节律系统的视交叉上核（SCN）中的中央光携带时钟已经进化出一个相互依赖的信号机制的复杂网络，将多个不同的振荡器连接起来，以服务于这一关键功能。然而，控制SCN发育机制的研究远远落后于我们对其生理功能的理解。我们回顾了对成人SCN功能的理解进展，迄今为止关于SCN发展的描述，以及当前和未来SCN发展研究的潜力，以产生对主时钟功能，功能障碍和进化的重要见解。
The circadian system constrains an organism's palette of behaviors to portions of the solar day appropriate to its ecological niche. The central light-entrained clock in the suprachiasmatic nucleus (SCN) of the mammalian circadian system has evolved a complex network of interdependent signaling mechanisms linking multiple distinct oscillators to serve this crucial function. However, studies of the mechanisms controlling SCN development have greatly lagged behind our understanding of its physiological functions. We review advances in the understanding of adult SCN function, what has been described about SCN development to date, and the potential of both current and future studies of SCN development to yield important insights into master clock function, dysfunction, and evolution.