Impaired cognitive performance under psycho-social stress in cannabis dependence is mediated by attenuated precuneus activity
Impaired cognitive performance under psycho-social stress in cannabis dependence is mediated by attenuated precuneus activity
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DOI：
10.1101/429951
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发表时间：
2018-09
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影响因子：
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通讯作者：
Weihua Zhao;Kaeli Zimmermann;Xinqi Zhou;F. Zhou;M. Fu;Christian Dernbach;D. Scheele;B. Weber;M. Eckstein;R. Hurlemann;K. Kendrick;B. Becker
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文献类型：
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作者：
Weihua Zhao;Kaeli Zimmermann;Xinqi Zhou;F. Zhou;M. Fu;Christian Dernbach;D. Scheele;B. Weber;M. Eckstein;R. Hurlemann;K. Kendrick;B. Becker
压力调节不足在物质使用、成瘾和复发的升级中起着重要作用。越来越多的证据表明，大麻依赖性的认知和奖励相关过程以及潜在的神经回路失调。然而，压力调节的改变还没有得到系统的研究。在此背景下，本fMRI研究探讨了心理社会压力处理大麻依赖的男性和匹配的控制使用自适应心算任务伴随着负面的社会评价。在心理社会压力暴露期间，而不是在非压力条件下，大麻使用者表现出性能下降。与此相反，经验丰富的压力和心血管应激反应的水平没有显着差异，从控制。神经影像学数据显示，大麻使用者的压力引起的性能恶化伴随着楔前叶活动减少和该区域与背内侧前额叶皮层的连接增加。总之，本研究结果提供了第一个证据，证明大麻使用者的过度压力引起的认知能力恶化。神经数据表明，缺乏压力相关的动力学楔前叶可能介导的行为水平上的性能恶化。
Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, alterations in stress regulation have not been systematically examined. Against this background the present fMRI study examined psycho-social stress processing in cannabis-dependent males and matched controls using an adaptive mental arithmetic task accompanied by negative social evaluation. During psycho-social stress exposure, but not the non-stress condition, cannabis users demonstrated decreased performance. In contrast, levels of experienced stress and cardiovascular stress responsivity did not differ from controls. Neuroimaging data revealed that stress-induced performance deteriorations in cannabis users were accompanied by decreased precuneus activity and increased connectivity of this region with the dorsal medial prefrontal cortex. Together, the present findings provide the first evidence for exaggerated stress-induced cognitive performance deteriorations in cannabis users. The neural data suggests that deficient stress-related dynamics of the precuneus may mediate the deterioration of performance on the behavioral level.