Introduction of a retention interval in a sustained attention task in rats: effects of a visual distracter and increasing the inter-trial interval
Introduction of a retention interval in a sustained attention task in rats: effects of a visual distracter and increasing the inter-trial interval
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DOI：
10.1016/j.beproc.2004.08.009
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发表时间：
2004-11-30
影响因子：
1.3
通讯作者：
Burk, JA
中科院分区：
文献类型：
--
作者：
Burk, JA
操纵外显注意力需求对工作记忆的影响尚未在啮齿类动物中得到很好的研究。本实验旨在测试在两级持续注意力任务中加入保持间隔的效果，该任务需要对视觉信号和非信号进行区分，之前已经证明该任务可以有效地测量大鼠的注意力。在建立基线表现后，进行了额外的操作，包括视觉干扰的呈现和增加试验间隔的长度和可变性。在基线条件下，信号的准确检测，而不是非信号，随着保持时间的增加而下降。在整个会议期间，闪烁的室内灯光消除了信号的延迟相关检测。延长试验间隔提高了信号的检测，减少了最长保留间隔下非信号的检测。最后，增加试验间隔的可变性对性能的影响并不显著，超出了增加试验间隔的影响。本实验证明外显注意需求的操纵可以改变大鼠的工作记忆表现。这项任务可以用来了解神经药理学和神经解剖学的基础，介导记忆时，注意负荷是系统变化的。(C) 2004 Elsevier b.v.版权所有
The impact of manipulating explicit attentional demands on working memory has not been well studied in rodents. The present experiment was designed to test the effects of incorporating a retention interval in a two-lever sustained attention task that requires discrimination of visual signals and non-signals and that has previously been shown to yield valid measures of attention in the rat. Upon establishing baseline performance, additional manipulations, including presentation of a visual distracter and increasing the length and variability of the inter-trial interval were conducted. During baseline conditions, accurate detection of signals, but not non-signals, decreased as the retention interval was increased. Presentation of a flashing houselight throughout the session eliminated delay-dependent detection of signals. Increasing the inter-trial interval improved detection of signals and decreased detection of non-signals at the longest retention interval. Finally, increasing the variability of the inter-trial interval did not have significant effects on performance above and beyond the effects of increasing the inter-trial interval. The present experiment demonstrates that manipulation of explicit attentional demands can alter working memory performance in the rat. This task may be employed to understand the neuropharmacological and neuroanatomical substrates mediating memory while attentional load is systematically varied. (C) 2004 Elsevier B.V All rights reserved.