Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing
Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing
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DOI：
10.1002/adfm.202202285
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发表时间：
2022-04-09
影响因子：
19
通讯作者：
Liu, Ji
中科院分区：
文献类型：
--
作者：
Chen, Xingmei;Zhang, Jun;Liu, Ji
水凝胶生物粘合剂由于其在生物相容性、机械顺应性和微创操作方面的独特优势，已成为缝合线和斯台普斯用于伤口密封和修复的最有前途的替代品之一。然而，只有少数水凝胶生物粘合剂已经成功地用于胃穿孔修复，这是由于它们在与极酸性胃液直接接触时不期望的溶胀，从而伴随着逐渐恶化的粘合性能。本文中，开发了一种耐酸水凝胶（ATGel）生物粘附剂，其整合了两种不同的组分，耐酸水凝胶基底和粘附性聚合物刷层。ATGel生物粘合剂可对胃穿孔形成即时、无创、液密和无缝线密封，并实现与胃液直接接触的坚固生物界面，解决了缝线和市售组织粘合剂的关键局限性。此外，在大鼠胃穿孔模型的体内研究验证了所提出的耐酸生物粘附，并确定了通过减轻炎症，抑制纤维化和促进血管生成来加速胃穿孔修复的机制。
Hydrogel bioadhesives have emerged as one of the most promising alternatives to sutures and staples for wound sealing and repairing, owing to their unique advantages in biocompatibility, mechanical compliance, and minimally invasive manipulation. However, only a few hydrogel bioadhesives have been successfully used for gastric perforation repair, due to their undesirable swelling when in direct contact with extremely acidic gastric fluids, and are thereby accompanied by a gradually deteriorating adhesion performance. Herein, an acid-tolerant hydrogel (ATGel) bioadhesive is developed, which integrates two distinct components, an acid-tolerant hydrogel substrate and an adhesive polymer brush layer. The ATGel bioadhesive can form instant, atraumatic, fluid-tight, and sutureless sealing of gastric perforation, and enable robust biointerfaces in direct contact with gastric fluids, addressing the key limitations with sutures and commercially-available tissue adhesives. Moreover, in vivo investigation on gastric perforation of rat model validates the proposed acid-tolerant bioadhesion, and identifies the mechanisms for accelerated gastric perforation repair through alleviated inflammation, which suppresses fibrosis and enhances angiogenesis.