Promising approaches to circumvent the blood-brain barrier: progress, pitfalls and clinical prospects in brain cancer.
Promising approaches to circumvent the blood-brain barrier: progress, pitfalls and clinical prospects in brain cancer.
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DOI：
10.4155/tde.15.48
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发表时间：
2015
影响因子：
4.2
通讯作者：
Porter T
中科院分区：
文献类型：
--
作者：
Papademetriou IT;Porter T
脑内给药是中枢神经系统疾病治疗的主要挑战。药物或药物纳米载体的生物化学修饰、局部递送方法以及用聚焦超声和微泡破坏血脑屏障（BBB）是增强运输或绕过BBB的有前景的方法。这些方法在脑癌的背景下进行了讨论，作为CNS药物开发的一个例子。靶向受体，使运输通过血脑屏障提供了小分子和生物癌症治疗的非侵入性递送。局部递送方法能够实现高剂量递送，同时避免全身暴露。聚焦超声和微泡破坏BBB提供局部和非侵入性治疗。临床试验显示了这些技术的前景，并指出了未来的挑战。
Brain drug delivery is a major challenge for therapy of central nervous system (CNS) diseases. Biochemical modifications of drugs or drug nanocarriers, methods of local delivery, and blood–brain barrier (BBB) disruption with focused ultrasound and microbubbles are promising approaches which enhance transport or bypass the BBB. These approaches are discussed in the context of brain cancer as an example in CNS drug development. Targeting to receptors enabling transport across the BBB offers noninvasive delivery of small molecule and biological cancer therapeutics. Local delivery methods enable high dose delivery while avoiding systemic exposure. BBB disruption with focused ultrasound and microbubbles offers local and noninvasive treatment. Clinical trials show the prospects of these technologies and point to challenges for the future.