FUNCTIONAL DEVELOPMENT OF DORSOLATERAL PREFRONTAL CORTEX - ANALYSIS UTILIZING REVERSIBLE CRYOGENIC DEPRESSION
FUNCTIONAL DEVELOPMENT OF DORSOLATERAL PREFRONTAL CORTEX - ANALYSIS UTILIZING REVERSIBLE CRYOGENIC DEPRESSION
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DOI：
10.1016/0006-8993(78)90566-8
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发表时间：
1978-01-01
期刊：
影响因子：
2.9
通讯作者：
GOLDMAN, PS
中科院分区：
文献类型：
--
作者：
ALEXANDER, GE;GOLDMAN, PS
The dorsolateral prefrontal cortex of rhesus monkeys was functionally inactivated by local hypothermia as the monkeys performed spatial delayed-response and spatial delayed-alternation tasks at different stages of postnatal development. Cryogenic depression of prefrontal cortex at a temperature sufficient to induce 21-25% decrements in delayed-response performance in 34-36 mo. old monkeys produced deficits of only 7-8% in 19-31 mo. olds and no detectable loss in younger monkeys, 9-16 mo. old. Delayed-alternation performance was impaired by local hypothermia as early as 8.5 mo. old, but maximal cooling-induced deficits on this task were not observed before 33 mo. old. Thermal gradients mapped in representative monkeys at different developmental stages were remarkably similar, indicating that the age-dependent differences in behavior were not attributable to technical factors. These results on normal developing monkeys confirmed the interpretation of previous research on brain-damaged infants that functional maturation of the dorsolateral prefrontal cortex is protracted over several years of postnatal life, and extended the earlier studies by indicating that the lower limit for maturity of dorsolateral function is close to puberty in this species. Apparently delayed-response and delayed-alternation performance are dissociable dorsolateral functions which achieve maturity at different rates. The convergence of evidence from reversible neural depression and permanent lesion methods provides strong validation for neurobehavioral analysis as a general approach to the study of regional brain maturation.
