Evidence for autonomic nervous system imbalance in women with irritable bowel syndrome
Evidence for autonomic nervous system imbalance in women with irritable bowel syndrome
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DOI：
10.1023/a:1018871617483
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发表时间：
1998-09-01
影响因子：
3.1
通讯作者：
Bond, EF
中科院分区：
文献类型：
--
作者：
Heitkemper, M;Burr, RL;Bond, EF
采用心率变异性的频域测量方法评估了患有和不患有肠易激综合征的女性的自主神经系统功能。根据诊断史和当前胃肠道症状的自我报告，对女性进行访谈并将其放入肠易激综合征组（N = 25）。对照组女性否认慢性胃肠道症状史（N = 15）。研究人员用症状日记跟踪妇女一个月经周期，并在黄体中期佩戴霍尔特24小时心电图监测仪。肠易激综合征妇女表现出显着较低的迷走神经张力测量的高频频谱相对于对照组妇女。此外，患有肠易激综合征的女性有一个平坦的24小时心率变异性模式，睡眠期间迷走神经张力水平显着降低。这些结果表明，全身交感迷走神经的平衡可能会改变一个子集的妇女肠易激综合征。
Autonomic nervous system function was assessed in women with and without irritable bowel syndrome using frequency domain measures of heart rate variability. Women were interviewed and placed into the irritable bowel syndrome (N = 25) group based on history of diagnosis and self-report of current gastrointestinal symptoms. Women in the control group denied a history of chronic gastrointestinal symptoms (N = 15). Women were followed for one menstrual cycle with a symptom diary, and during mid-luteal phase they wore a Holter 24-hr electrocardiograph monitor. Women with irritable bowel syndrome demonstrated significantly lower vagal tone as measured by the high frequency spectrum relative to control women. In addition, women with irritable bowel syndrome had a flattened 24-hr pattern of heart rate variability, with significantly lower levels of vagal tone during sleep. These results suggest that systemic sympathovagal balance may be shifted in a subset of women with irritable bowel syndrome.