Smoking and Parkinson's disease.
Smoking and Parkinson's disease.
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DOI：
10.1002/mds.870090215
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发表时间：
1982-07
期刊：
影响因子：
--
通讯作者：
R. Mayeux;M. Tang;K. Marder;L. Cote;Y. Stern
中科院分区：
文献类型：
--
作者：
R. Mayeux;M. Tang;K. Marder;L. Cote;Y. Stern
在一项关于吸烟习惯与帕金森氏症关系的病例对照研究中，结果显示，吸烟习惯与帕金森病之间存在负相关，其相对风险为0×52。20年前的吸烟史与患帕金森氏症的风险相当，约为不吸烟者的一半。疾病的类型、发病年龄和进展速度与类似的风险降低相关，这意味着就吸烟史而言，这种疾病是同质的。退行性血管疾病与吸烟的正相关进一步证明动脉硬化与帕金森病的病因无关。帕金森氏症与吸烟之间的负关联已得到证实，并且与其他相关因素无关。吸烟已知的严重风险远远超过降低帕金森氏症风险可能带来的好处。
In a case control study of the relationship between smoking habits and Parkinson's disease a negative association was demonstrated with a relative risk of 0 x 52. A history of smoking up to 20 years earlier was associated with a risk of developing Parkinson's disease equal to about half that in non-smokers. The type of disease, age of onset and rate of progression were associated with a similar reduction in risk implying that in respect of smoking history the disease is homogeneous. The positive correlation of degenerative vascular disease with smoking is further evidence that arteriosclerosis is not involved in the causation of Parkinson's disease. The negative association between Parkinson's disease and smoking is confirmed and is independent of other associated factors. The known and serious risks of smoking far outweigh the possible benefit of lowered risk of Parkinson's disease.