Modification of high saturated fat diet with n-3 polyunsaturated fat improves glucose intolerance and vascular dysfunction.
Modification of high saturated fat diet with n-3 polyunsaturated fat improves glucose intolerance and vascular dysfunction.
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DOI：
10.1111/dom.12004
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Yorek MA
中科院分区：
文献类型：
--
作者：
Lamping KG;Nuno DW;Coppey LJ;Holmes AJ;Hu S;Oltman CL;Norris AW;Yorek MA
The ability of dietary enrichment with monounsaturated (MUFA), n-3, or n-6 polyunsaturated fatty acids (PUFA) to reverse glucose intolerance and vascular dysfunction resulting from excessive dietary saturated fatty acids is not resolved. We hypothesized that partial replacement of dietary saturated fats with n-3 PUFA enriched menhaden oil (MO) would provide greater improvement in glucose tolerance and vascular function compared to n-6 enriched safflower oil (SO) or MUFA-enriched olive oil (OO). We fed mice a high saturated fat diet (60% kcal from lard) for 12 weeks before substituting half the lard with MO, SO or OO for an additional 4 weeks. At the end of 4 weeks, we assessed glucose tolerance, insulin signaling and reactivity of isolated pressurized gracilis arteries. After 12 weeks of saturated fat diet, body weights were elevated and glucose tolerance abnormal compared to mice on control diet (13% kcal lard). Diet substituted with MO restored basal glucose levels, glucose tolerance, and indices of insulin signaling (phosphorylated Akt) to normal whereas restoration was limited for SO and OO substitutions. Although dilation to acetylcholine was reduced in arteries from mice on HF, OO and SO diets compared to normal diet, dilation to acetylcholine was fully restored and constriction to phenylephrine reduced in MO fed mice compared to normal. We conclude that short term enrichment of an ongoing high fat diet with n-3 PUFA rich MO but not MUFA rich OO or n-6 PUFA rich SO reverses glucose tolerance, insulin signaling, and vascular dysfunction.
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影响因子：
20.1
作者：
Symons JD;McMillin SL;Riehle C;Tanner J;Palionyte M;Hillas E;Jones D;Cooksey RC;Birnbaum MJ;McClain DA;Zhang QJ;Gale D;Wilson LJ;Abel ED
通讯作者：
Abel ED
影响因子：
5.8
作者：
Degirolamo, Chiara;Rudel, Lawrence L.
通讯作者：
Rudel, Lawrence L.
DOI：
10.1161/atvbaha.108.169722
发表时间：
2008-11
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Kim F;Pham M;Maloney E;Rizzo NO;Morton GJ;Wisse BE;Kirk EA;Chait A;Schwartz MW
通讯作者：
Schwartz MW
影响因子：
3.6
作者：
Ramsden, Christopher E.;Hibbeln, Joseph R.;Majchrzak, Sharon F.;Davis, John M.
通讯作者：
Davis, John M.
影响因子：
4.7
作者：
YOREK, MA;STROM, DK;SPECTOR, AA
通讯作者：
SPECTOR, AA