A novel metronidazole electrochemical sensor based on surface imprinted vertically cross-linked two-dimensional Sn3O4 nanoplates
A novel metronidazole electrochemical sensor based on surface imprinted vertically cross-linked two-dimensional Sn3O4 nanoplates
复制标题
基于表面印迹垂直交联二维Sn3O4纳米板的新型甲硝唑电化学传感器
DOI：
10.1039/c8ay01824c
复制
发表时间：
2018
影响因子：
3.1
通讯作者：
X. Hu
中科院分区：
文献类型：
--
作者：
J. Wang;W. Du;X. Huang;J. Hu;W. Xia;D. Jin;Y. Shu;Q. Xu;X. Hu
本工作以甲硝唑（MNZ）为模板、吡咯为功能单体、垂直交联二维Sn3O4（2D Sn3O4）纳米片为载体，制备了一种分子印迹聚合物（MIP）。通过 SEM、XRD、XPS 和 FT-IR 对所开发的 MIP/2D Sn3O4 进行了表征。它被用来修饰玻碳电极（GCE）来构建新型 MNZ 电化学传感器。对影响传感器性能的参数进行了彻底的研究和优化。结果表明，2D Sn3O4 作为 MNZ 印迹的支持材料很有前景。由于具有二维结构、大活性表面、功能化和高电导率，MIP/2D Sn3O4 修饰电极表现出较宽的线性范围和较低的检测限。 MIP/2D Sn3O4 电化学传感器产生的差分脉冲伏安峰值电流与 MNZ 浓度在 0.025–2.5 μM 范围内呈线性关系。该传感器的检测限低至 0.0032 μM (S/N = 3)。该MIP/2D Sn3O4传感器成功用于检测蜜蜂样品中的MNZ，无需任何分离或积累过程，表明MIP/2D Sn3O4是一种有前途的仿生材料，可用于电分析和其他相关领域。
In this work, a kind of molecularly imprinted polymer (MIP) was prepared by using metronidazole (MNZ) as the template, pyrrole as the functional monomer and vertically cross-linked two-dimensional Sn3O4 (2D Sn3O4) nanoplates as the support. The developed MIP/2D Sn3O4 was characterized by SEM, XRD, XPS and FT-IR. It was used to modify a glassy carbon electrode (GCE) to construct a novel MNZ electrochemical sensor. Parameters affecting the performance of the sensor were thoroughly investigated and optimized. The results revealed that 2D Sn3O4 is promising as a support for MNZ imprinting. Owing to the 2D structure, large active surface, functionalization and high electrical conductivity, the MIP/2D Sn3O4 modified electrode showed a wide linear range and low detection limit. The differential pulse voltammetric peak currents produced on the MIP/2D Sn3O4 electrochemical sensor showed a linear relationship for concentrations of MNZ in the range of 0.025–2.5 μM. The detection limit of this sensor was down to 0.0032 μM (S/N = 3). This MIP/2D Sn3O4 sensor was successfully used to detect MNZ in honeybee samples without any separation or accumulation processes, demonstrating that MIP/2D Sn3O4 is a promising biomimetic material for use in electroanalysis and other relevant fields.