CARRIER SOLUTIONS FOR LOW-LEVEL INTRAVENOUS INSULIN INFUSION
CARRIER SOLUTIONS FOR LOW-LEVEL INTRAVENOUS INSULIN INFUSION
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DOI：
10.1136/bmj.3.5981.464
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发表时间：
1975-01-01
影响因子：
--
通讯作者：
CHIA, YO
中科院分区：
文献类型：
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作者：
KRAEGEN, EW;LAZARUS, L;CHIA, YO
在使用低水平静脉内胰岛素输注治疗糖尿病性高血糖和酮症酸中毒时，胰岛素吸附到容器或塑料输注装置中导致稀释生理盐水溶液（40 U/l）中60-80%的胰岛素的显著损失。因此，有必要向载体溶液中添加蛋白质以使损失最小化并保持恒定的递送速率。回收率研究表明，3.5% w/v聚明胶肽溶液（降解明胶的聚合物）是用于此目的的合适介质，与人血清白蛋白相比具有一些优势。需要0.5%聚明胶肽的最低浓度，以确保向患者充分输送胰岛素。
In the use of low-level intravenous insulin infusion for treating diabetic hyperglycaemia and ketoacidosis adsorption of insulin to containers or plastic infusion apparatus results in significant losses of 60-80% of insulin in dilute physiological saline solution (40 U/l). It is therefore necessary to add protein to the carrier solution to minimize losses and maintain a constant delivery rate. Recovery studies showed that 3.5% w/v polygeline solution (polymer of degraded gelatin) was a suitable medium for this purpose, offering some advantages over human serum albumin. A minimum concentration of 0.5% polygeline was required to ensure adequate delivery of insulin to the patient.