The role of human decay-accelerating factor in the pathogenesis of preterm labor.
The role of human decay-accelerating factor in the pathogenesis of preterm labor.
复制标题
人类腐烂加速因子在早产发病机制中的作用。
DOI：
10.1055/s-0031-1274510
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发表时间：
2011
影响因子：
2
通讯作者：
Nowicki,BogdanJ
中科院分区：
文献类型：
--
作者：
Pacheco,LuisD;Hankins,GaryD;Costantine,MagedM;Anderson,GarlandD;Pawelczyk,Edyta;Nowicki,Stella;Nowicki,BogdanJ
Complement activation is thought to contribute to the pathogenesis of preterm labor (PTL). Decay-accelerating factor (DAF) is a natural complement pathway inhibitor. Our hypothesis was that DAF expression on maternal white blood cells (WBCs) in women with preterm labor is elevated compared with women with no preterm labor. Our secondary objective was to determine if differences in upregulation of DAF levels correlated with clinical outcomes. Serial blood samples were obtained from 30 patients with a clinical diagnosis of PTL and a control group of 30 pregnant individuals (same gestational age range) to determine DAF expression in peripheral WBCs in both groups. DAF expression was higher in women with PTL (less than 37 weeks) compared with the control group without PTL. Subjects with PTL who delivered before 34 weeks had less DAF expression and different kinetics of expression compared with those carrying pregnancies beyond 34 weeks. These data suggest that women with a clinical diagnosis of preterm labor have increased DAF expression on peripheral WBCs. Furthermore, it appears that failure to elevate DAF expression is associated with a risk of early premature delivery.
唾液酸、代谢和功能：由 R. Schauer 编辑，Springer-Verlag，维也纳和纽约，1982 年，xix 320 页主题索引，65.60 美元，DM 164.00
DOI：
--
发表时间：
1984
期刊：
影响因子：
--
作者：
S. Tanenbaum
通讯作者：
S. Tanenbaum