Dextran sulfate sodium (DSS)-induced colitis in mice.
Dextran sulfate sodium (DSS)-induced colitis in mice.
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DOI：
10.1002/0471142735.im1525s104
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发表时间：
2014-02-04
影响因子：
--
通讯作者：
Vijay-Kumar, Matam
中科院分区：
文献类型：
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作者：
Chassaing, Benoit;Aitken, Jesse D;Malleshappa, Madhu;Vijay-Kumar, Matam
炎症性肠病（IBD）是一种病因不明的复杂多因素疾病，主要包括溃疡性结肠炎和克罗恩病。在过去的20年里，为了研究人类IBD的机制，已经建立了许多小鼠结肠炎模型。这些模型是解释IBD发病机制以及评估许多潜在治疗方法不可或缺的工具。在各种化学诱导结肠炎模型中，dss诱导结肠炎模型因其简单且与人类溃疡性结肠炎有许多相似之处而被广泛应用。这种模式有优点也有缺点，在使用时需要考虑。目前的方案旨在广泛描述dss诱导的结肠炎模型，重点关注其详细的方案以及可能影响dss诱导的病理的因素。
Inflammatory bowel diseases (IBD) mainly comprised of Ulcerative Colitis and Crohn's Disease are complex and multifactorial disease with unknown etiology. For the past 20 years, to study human IBD mechanistically, number of murine models of colitis has been developed. These models are indispensable tools to decipher underlying mechanisms of IBD pathogenesis as well as to evaluate number potential therapeutics. Among various chemical induced colitis models, DSS-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that need to be considered when employed. The current protocol aimed to extensively describe the DSS-induced colitis model, focusing on its detailed protocol as well as factors that could affect DSS-induced pathology.