Repairing a 35-mm-long median nerve defect with a chitosan/PGA artificial nerve graft in the human: A case study
Repairing a 35-mm-long median nerve defect with a chitosan/PGA artificial nerve graft in the human: A case study
复制标题
使用壳聚糖/PGA 人工神经移植物修复人体 35 毫米长的正中神经缺损：案例研究
DOI：
10.1002/micr.20488
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发表时间：
2008-01-01
期刊：
影响因子：
2.1
通讯作者：
Gu, Xiaosong
中科院分区：
文献类型：
--
作者：
Fan, Weimin;Gu, Jianhui;Gu, Xiaosong
我们研制了一种壳聚糖/聚乙醇酸(PGA)人工神经移植物，用于狗坐骨神经30 mm长缺损区的桥接移植。在这里，我们描述了一项临床试验，该移植物用于修复人类患者肘部35毫米长的正中神经缺损。术后随访3年，采用夹钳试验、液压手握力测定、静态两点辨别试验、单丝触觉试验，结合电生理检查，评价损伤正中神经功能恢复情况。术后正中神经运动和感觉功能持续恢复，随访期达到M-4和S-3+水平。结果表明，壳聚糖/PGA人工神经移植物可在较高水平上修复人体较大的周围神经缺损区。(C)2008年Wiley-Liss，Inc.
We have developed a chitosan/polyglycolic acid (PGA) artificial nerve graft which was previously used for bridge implantation of dog sciatic nerves across 30-mm long defects. Here we describe a clinical trial of this graft for repairing a 35-mm-long median nerve defect at elbow of a human patient. During the 3-year follow-up period, functional recovery of the injured median nerve was assessed by pinch gauge test, hydraulic hand clynamometry, static two-point discrimination and touch test with monofilaments, in couple with electrophysiological examinations. The motor and sensory function of the median nerve demonstrated an ongoing recovery postimplantation, reaching M-4 and S-3+ levels during the follow-up period. The results indicate that the chitosan/PGA artificial nerve graft could be used for surgical repair of larger defects in major peripheral nerves at a higher level in the human. (c) 2008 Wiley-Liss, Inc.